Basic Information
VIS ID
TVIS10016938
Fusion event
HBV-KMT2C integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
Start
1354
End
1443
Integrated sequence
CCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCT
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
End
152115453/152418368 (Hg38)
Location type
Intron
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-10399/Upstream/984648; hsa-mir-153-2/Downstream/5155968;
Nearest cancer related gene
KMT2C(TSG, No orient, 0)
Upstream sequence
tatgaggttatatatatatactgcaatttatttattattttcctgctaatagacattagggttgttctcaggtatttataattataaatgtgctattatg
Downstream sequence
gggtgagaagaggaaaaggggagacagctgtatggttacataaattatagtgtggttactcagttttttgttgttgttttgagacagagtctcgctctgt
Target sequence
ataaaaataaccaaaatatgaaaaaggctttatctacaaaaaggtcagccagagcattacacatagtaacaaaaggcagta
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate