Fusion event
HBV-KMT2C integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
CCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCT
End
152115453/152418368 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10399/Upstream/984648; hsa-mir-153-2/Downstream/5155968;
Nearest cancer related gene
Upstream sequence
tatgaggttatatatatatactgcaatttatttattattttcctgctaatagacattagggttgttctcaggtatttataattataaatgtgctattatg
Downstream sequence
gggtgagaagaggaaaaggggagacagctgtatggttacataaattatagtgtggttactcagttttttgttgttgttttgagacagagtctcgctctgt
Target sequence
ataaaaataaccaaaatatgaaaaaggctttatctacaaaaaggtcagccagagcattacacatagtaacaaaaggcagta
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.