Basic Information
VIS ID
TVIS10016939
Fusion event
HBV-KMT2C integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1897
End
1982
Integrated sequence
GGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTA
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
152115452/152418367 (Hg38)
End
152115540/152418455 (Hg38)
Location type
Intron
Fragile sites / regions
FRA7I
Target gene
KMT2C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-26b-5p ; hsa-mir-940 ; hsa-mir-708-5p ; hsa-mir-106b-3p ; hsa-mir-652-3p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-186-5p ; hsa-mir-15b-5p ; hsa-mir-196a-5p ; hsa-mir-610 ; hsa-mir-93-3p ; hsa-mir-4663 ; hsa-mir-4632-3p ; hsa-mir-6746-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-934
Nearest miRNA
hsa-mir-10399/Upstream/984728; hsa-mir-153-2/Downstream/5155881;
Nearest TSS
ENST00000635602/Upstream/106071; ENST00000564834/Downstream/17344;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/51372, chr7-CpG: 219/Downstream/16677
Nearest cancer related gene
KMT2C(TSG, No orient, 0)
Upstream sequence
AAACAAATATTTAGAAATTAGTTATGTTGTTATTTAGATATATGCTTAAGTGGGTGAAAATCCTGTAATTCCTGTTTGCCTGAAGCAAACTTAAATTTAT
Downstream sequence
agtctcgctctgtcgcccaggctggagtgcaatggtgtggtcttggctcactgcaacctccacctcccggattccagcgattctcctgcctcagcctcct
Target sequence
agggtgagaagaggaaaaggggagacagctgtatggttacataaattatagtgtggttactcagttttttgttgttgttttgagacag
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate