Basic Information
VIS ID
TVIS10016940
Fusion event
HBV-chr13 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1847
End
1933
Integrated sequence
TTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGC
Host Sequence
Chromosome
chr13
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
103983816/103331466 (Hg38)
End
103983876/103331526 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/1285462; hsa-mir-1267/Downstream/4199645;
Nearest TSS
ENST00000623511/Upstream/264620; ENST00000444795/Downstream/93674;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/485053, chr13-CpG: 29/Downstream/3161534
Upstream sequence
GCTTAGCTAATAAAAGGAAAACAAAAAAGTCTTAAGTAAAGATTAGCAGACAACTTTCCTCCCTGGAAATTCTCATTGAAATGATTACATGTTGGCCAAG
Downstream sequence
TTTATTCATTTATGTACTCACTTGGCCACTCACTTATGACAACTAAATTGTCCTCAGAGctgtggcttggcattgggaggaccatgatgaacagacagag
Target sequence
ATATTTCTTGTCTTATGAAGTTATCACAGTGGATGTATAAGATTTTTTAATACTAAAATC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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