Basic Information
VIS ID
TVIS10016943
Fusion event
HBV-chr2 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1798
End
1887
Integrated sequence
GTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTG
Host Sequence
Chromosome
chr2
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
117332228/116574652 (Hg38)
End
117332310/116574734 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/2853284; hsa-mir-10b/Downstream/10848803;
Nearest TSS
ENST00000437798/Upstream/759989; ENST00000489933/Downstream/1229440;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1411463, chr2-CpG: 48/Downstream/1239802
Upstream sequence
ttatgtggtccatttggaggtggttggcttcactgctttcctgtcgagcattggcatggcatcttGGGCTGCTGTCCCCAAAGACAGCTCTATTGATGTG
Downstream sequence
ttctttttcttttttattctctgaatatatttttaaatatcttgtgtttaagctgactaattatttattctccttgatccattctgctgttaaaggactc
Target sequence
ccaccttctcataaagaccagtaaagcttagatttgcaattttgaggttattttctagaggttgtaggcatgtttttattct
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate