Basic Information
VIS ID
TVIS10016944
Fusion event
HBV-chr14 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1998
End
2089
Integrated sequence
ACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGG
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
43221813/42752610 (Hg38)
End
43221913/42752710 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/5800219; hsa-mir-1185-1/Downstream/5008285;
Nearest TSS
ENST00000550708/Upstream/340037; ENST00000557465/Downstream/1631835;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/1145484, chr14-CpG: 22/Downstream/2134759
Upstream sequence
ATTCAGTGGCAGGTTCAGCATTCCCTGTGTGCAGTTCATAGGGCAAGGAAGACTGTAGGTAGTGAACTTCCCTTGAACTGAGACCCAGTCCTGTTTTCAT
Downstream sequence
aaacattgcatgttctcccttatttgtgggatctaaaaatcagaataattgaactcagacagagagagtagaagtaaggttaccagaggctaggaaacct
Target sequence
tattcagccgtaaaaaaagaatgaaatccagttatttgcaacaacaaggatgggactgaagatcattatgttaagtgaaattatccaggcacagaaagac
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate