Basic Information
VIS ID
TVIS10016949
Fusion event
HBV-chr7 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1820
End
1910
Integrated sequence
ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATC
Host Sequence
Chromosome
chr7
Cytoband
p13
Reference genome
GRCh37/hg19
Start
44132757/44093158 (Hg38)
End
44132856/44093257 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA7D
Nearest miRNA
hsa-mir-1183/Upstream/19725; hsa-mir-10399/Downstream/17592;
Nearest TSS
ENST00000635602/Upstream/10618; ENST00000449162/Downstream/11104;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/10095, chr7-CpG: 66/Downstream/11036
Upstream sequence
catgttcacctgttccaaagattaggatgtggatatctttggggagccacgaatcagctaccacaATGGCACTTCGATTGTCTGAATTTGCCTTGTAGCT
Downstream sequence
gggtggatcctcatgaagtgccctccccattggggtaatgagctctcactctaaacagatctgtttgtttaagagcctggaacttcctcctctctctctt
Target sequence
ATCCGACCtggtttgcatgtttgtccccttcaggtctcatgttgaaatgtgatccccagtgttggaagtggggcctggtgagaggtgtgtgggtcatgg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate