Basic Information
VIS ID
TVIS10016950
Fusion event
HBV-LINC00957 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1159
End
1248
Integrated sequence
GCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTT
Host Sequence
Chromosome
chr7
Cytoband
p13
Reference genome
GRCh37/hg19
Start
44080861/44041262 (Hg38)
End
44080950/44041351 (Hg38)
Location type
Intron
Fragile sites / regions
FRA7D
Target gene
LINC00957
Nearest miRNA
hsa-mir-1183/Upstream/890268; hsa-mir-10399/Downstream/10415;
Nearest TSS
ENST00000635602/Upstream/1739; ENST00000439983/Downstream/3289;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/293, chr7-CpG: 40/Downstream/3156
Upstream sequence
TTAAATCAGAAAATCTTCAGAAAGGAGGCTTGGATCTTATCTACTTATGTTCCAGGACAGACAAAATCTTAGCTTTGACTTTTGATTCCATAAACATTCG
Downstream sequence
gggcaacatagtgagactgtctctaACTTAAATTTTAATCACACACACATTCTTTTGGGGGGGGGGGGTGCGGGGCacggagtctagcacggggcccagg
Target sequence
atgaCTAGAATTCTTAGCCcttgtaatcctagcactttgggaggccgaggcaggaggatcacttgaggccaggagtttgagaccagcct
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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