Basic Information
VIS ID
TVIS10016951
Fusion event
HBV-FAM92A integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2396
End
2485
Integrated sequence
ACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTA
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
94729084/93716856 (Hg38)
End
94729182/93716954 (Hg38)
Location type
Intron
Fragile sites / regions
FRA8B
Target gene
FAM92A
miRNAs that regulate target gene
hsa-mir-708-5p
Nearest miRNA
hsa-mir-12123/Upstream/687017; hsa-mir-10400/Downstream/199068;
Nearest TSS
ENST00000518652/Upstream/743; ENST00000520562/Downstream/2620;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/15739, chr8-CpG: 44/Downstream/23793
Upstream sequence
gtcagtccataaaaattggacattttgttttagaattattggaagtcatactatggccacaatcattagctactatcaagtatccaagccaaagccagac
Downstream sequence
TTGTTAATCAAACAAGATGGATGCTTTACTGTTAGTCATTACATCCAATTTAgctagttgactttgttgttcttgttgagacagaagtctccaaatgttg
Target sequence
agttctcttacatcctttattgaatatcctatACGCTGGAGAGCTGTCATTTCCTCTTTGCGAAAATGTTCTTAAAACCTTTTCGTTAAAGATCTCTT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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