Basic Information
VIS ID
TVIS10016957
Fusion event
HBV-chr5 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2904
End
2999
Integrated sequence
TGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAG
Host Sequence
Chromosome
chr5
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
70964752/71668925 (Hg38)
End
70964828/71669001 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/11965222; hsa-mir-103a-1/Downstream/500466;
Nearest TSS
ENST00000502646/Upstream/42271; ENST00000296777/Downstream/50162;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/81339, chr5-CpG: 63/Downstream/50089
Upstream sequence
aagaagaaaagagagatgaatcaaatagacacaataaaaaatgataaacaggagattaccactgattgcaacagaaatacaaattaccattatagaatac
Downstream sequence
gctgggtgtgatggtgtgcacctgtaatcccagctacttgggaggttaaggcaggagaattgcttgaacctgggaggcagaggttgcagtgagccaagat
Target sequence
gatcatgaggtcaggagttcgagaccagactggtcaacatggtgaaaccccatctctactaaaaatacaaaaatta
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate