Basic Information
VIS ID
TVIS10016958
Fusion event
HBV-chr5 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1819
End
1908
Integrated sequence
AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
Host Sequence
Chromosome
chr5
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
71074985/71779158 (Hg38)
End
71075049/71779222 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/12075455; hsa-mir-103a-1/Downstream/390245;
Nearest TSS
ENST00000502646/Upstream/59579; ENST00000504183/Downstream/328012;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/59270, chr5-CpG: 160/Downstream/327828
Upstream sequence
GCCGCGAGGAGAgggcggggccgcggaaaggaaggggaggggctgggagggcccggagggggctgggccggggacccgggaggggtcgggacggggcggg
Downstream sequence
AGGTAAACAGAAATGTCAGTTTGTGAATGCTTTTCGTATTCACTGCAACATTACTTTCTAAGGCGTGCGACACTGAAGGAATGTACTCACACTTATGTAA
Target sequence
ATATTGTCAGATATTAAATAATAGGAGAAACATCATCATTCAGAGATGCTGCTAACTACCACTT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate