VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10016962

Fusion event

HBV-YAP1 integration

Validated

No

Detection method

Capture-NGS platform

Data source

Curated

Sample type

Tumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2019

PubMed ID

30070724

Virus Sequence

Virus name

HBV

Subtype

B

Reference genome

NC_003977

Start

2238

End

2328

Integrated sequence

GAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACAC

Host Sequence

Chromosome

chr11

Cytoband

q22.1

Reference genome

GRCh37/hg19

Start

102024590/102153859 (Hg38)

End

102024638/102153907 (Hg38)

Location type

Intron

Target gene

YAP1

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-630 ; hsa-mir-375 ; hsa-mir-200a-3p ; hsa-mir-26b-5p ; hsa-mir-141-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-559 ; hsa-mir-548b-5p ; hsa-mir-548a-5p ; hsa-mir-548c-5p ; hsa-mir-548d-5p ; hsa-mir-1468-3p ; hsa-mir-877-5p ; hsa-mir-548j-5p ; hsa-mir-548k ; hsa-mir-548l ; hsa-mir-548h-5p ; hsa-mir-548p ; hsa-mir-548i ; hsa-mir-3121-3p ; hsa-mir-3125 ; hsa-mir-3159 ; hsa-mir-548w ; hsa-mir-3916 ; hsa-mir-548y ; hsa-mir-548o-5p ; hsa-mir-548ab ; hsa-mir-548ad-5p ; hsa-mir-548ae-5p ; hsa-mir-548ak ; hsa-mir-548am-5p ; hsa-mir-548ap-5p ; hsa-mir-548aq-5p ; hsa-mir-548ar-5p ; hsa-mir-548as-5p ; hsa-mir-548au-5p ; hsa-mir-548av-5p ; hsa-mir-548ay-5p ; hsa-mir-6859-5p ; hsa-mir-8054 ; hsa-mir-548bb-5p ; hsa-mir-506-3p ; hsa-mir-4639-5p ; hsa-mir-6844 ; hsa-mir-138-2-3p ; hsa-mir-4272 ; hsa-mir-4729 ; hsa-mir-10a-3p ; hsa-mir-509-3p ; hsa-mir-27a-3p ; hsa-mir-195-5p ; hsa-mir-424-3p ; hsa-mir-199a-3p ; hsa-mir-138-5p

Nearest miRNA

hsa-mir-10392/Upstream/633954; hsa-let-7a-2/Downstream/1695999;

Nearest TSS

ENST00000527297/Upstream/41345; ENST00000526594/Downstream/8549;

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/42260, chr11-CpG: 19/Downstream/114786

Nearest cancer related gene

YAP1(OG, No orient, 0)

Upstream sequence

catggtggtgtgtgcctgtagtcccagctactggggggccaaggcaggaggattgcttgagtctgggagtttgagactgtagtaagctgtgatcatgcac

Downstream sequence

TCCTCATGTAACACTAAAGATCCAGCCTGCTAGCATGGGTCTCATAGATTGAGGCAGTCTCTAAGTGATCATGTTACTTAATATTTACAGTATAACCTTT

Target sequence

AAAAAAATCTGTAAGACCTAGAAACCTGTGAACCCACCTTCTGTGTAA

Reference

Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.