Basic Information
VIS ID
TVIS10016963
Fusion event
HBV-chr12 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2140
End
2231
Integrated sequence
CGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTT
Host Sequence
Chromosome
chr12
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
30573669/30420736 (Hg38)
End
30573763/30420830 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1244-3/Upstream/4546657; hsa-let-7i/Downstream/11902870;
Nearest TSS
ENST00000382841/Upstream/99902; ENST00000500076/Downstream/216319;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/219057, chr12-CpG: 68/Downstream/274500
Upstream sequence
ctctcctgggaggtttttttaaggattaagtgaagtaaGTGGGGCATTGCTATACAATGTACTTTGTTATCCTTATTAAAACAAGAATCAAACAATCTAG
Downstream sequence
AAATGCAACTTTTTGTTCAACAGCAAAGTCGGAGAGCAAACTCTTTGTCAAGGCATTTATTTTAGTCGATTATTAATATGTCATCTGTGAAGTTATTCTC
Target sequence
TCTTCTTTTGTGGTTGTTCATAAAACATCTTGCAACCTTTGCTGGATTTTTTTCATTCTCCTAGGTGGTGGGGTTGAAACAAAACAAACAATAG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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