Basic Information
VIS ID
TVIS10016964
Fusion event
HBV-chr13 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1158
End
1250
Integrated sequence
GGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTT
Host Sequence
Chromosome
chr13
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
74010423/73436286 (Hg38)
End
74010524/73436387 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA13E
Nearest miRNA
hsa-mir-1297/Upstream/7217962; hsa-mir-1267/Downstream/4261625;
Nearest TSS
ENST00000623511/Upstream/361271; ENST00000430033/Downstream/110454;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/376054, chr13-CpG: 31/Downstream/697585
Upstream sequence
ATATTACCAGGAGAATGGGCTAGAGGATTTGTTATGTATCTGATGGCTTGATTTAGTGACTCAGCTTTCTGTACATTGAAAGTTGTCCTTATTAAAGCAA
Downstream sequence
agctcccactcataagtgagaacattcagtatttgacattttgtttccgagttgtttcacttaggataatgggcctctagttccatccatgttgccgcaa
Target sequence
gttaagtaatttcccatccctcaccccctccctctctcccacctttccaaatcttcagtgtctattattccacactctatgtccatgtgtacactttattt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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