GPHN _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016966
Fusion event
HBV-GPHN integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
35
End
124
Integrated sequence
CAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAAT
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
67900387/67433670 (Hg38)
End
67900483/67433766 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
GPHN
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-375
Nearest miRNA
hsa-mir-208a/Upstream/1962484; hsa-mir-1185-1/Downstream/8089;
Nearest TSS
ENST00000550708/Upstream/21470; ENST00000561456/Downstream/33580;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/21220, chr14-CpG: 40/Downstream/39691
Upstream sequence
AACAAATTCAAGCTATTTAAAGACTTGATATAAGATGAATAAGCATCAACACAATGCTACAAGAAAGAATCACTGTTTAACAAATATCGTCTAAGTGGGT
Downstream sequence
CTATTTAAAGACTTGATATAAGATGAATAAGCATCAACACAATGCTACAAGAAAGAATCACTGTTTAACAAATATCGTCTAAGTGGGTCATAAAAAGCCA
Target sequence
TTAAAAAAGCAGTCATCACTATATTTCACTGGGGTAAAGACAAGAAAAGTTGGCCAGGGTAATAGAAGAGACATACTCTACAGAAACAAATTCAAG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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