Basic Information
VIS ID
TVIS10016967
Fusion event
HBV-chr5 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1737
End
1827
Integrated sequence
GGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
3968806/3968692 (Hg38)
End
3968904/3968790 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-4277/Upstream/2259824; hsa-mir-10397/Downstream/2859063;
Nearest TSS
ENST00000502646/Upstream/368504; ENST00000503415/Downstream/44859;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/6294, chr5-CpG: 39/Downstream/897414
Nearby gene
LOC105374626(-4686) ;
Upstream sequence
CTGCAACACTTCCCCGCGACTTGGGCTCCTTGACACAGGCCCGTCATTTCTCTTTGCAGGTTCTCAGGCGGCGAGGGGTCCCCACCATGAGCAAACCACC
Downstream sequence
agataataaaagctatgaaacaaatagaaattgtagagctgaaaataaacatcttaaatttaaaatatgtcattggaaggactTCCAGTTTCAGTTCTTa
Target sequence
tggcctggaactcctgacctcaagtgatctgcccgcctcggcctcccaaagccctgggattacatgcatgaaccactatgcctggtgggaatctcaat
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate