Fusion event
HBV-chr13 integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
TCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCA
End
54873865/54299730 (Hg38)
Nearest miRNA
hsa-mir-15a/Upstream/1489516; hsa-mir-1267/Downstream/12242;
Upstream sequence
taaatatagctacttttgttatctttccttttttaattgcatgcaatatatctttccttctgttcactttcagtctgtctttatagatgtagtgatttct
Downstream sequence
taatctttcttactgtcttcctttgtggtcaactatttttcttctgtggtatgtattaatttaatgcattttcattttagggcatctgttgtagattttt
Target sequence
aggtgacaacttactactgccattttgttgcttgtttcctagttgttttgtaactcttgtcttttttttttttt
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.