Basic Information
VIS ID
TVIS10016973
Fusion event
HBV-chr5 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2124
End
2213
Integrated sequence
AATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCAC
Host Sequence
Chromosome
chr5
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
8223492/8223379 (Hg38)
End
8223582/8223469 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-4277/Upstream/1395458; hsa-mir-10397/Downstream/237456;
Nearest TSS
ENST00000502646/Upstream/299087; ENST00000605918/Downstream/222066;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/353652, chr5-CpG: 88/Downstream/233850
Upstream sequence
gaaaggaaggggaggggctgggagggcccggagggggctgggccggggacccgggaggggtcgggacggggcggggtccgcgcggaggaggcggagctgg
Downstream sequence
aagaagtcaaatctctgaatagaccaataagaagttctgaaattgaggcagtaattaatagcctatcaaccaaaaaaagcccaagactagacaaattcat
Target sequence
actataaacacctctatgaaaataaactagaaaatctagaggaaatggataaattcctggacacatacacactcccaagactaaaccagg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate