Basic Information
VIS ID
TVIS10016974
Fusion event
HBV-chr1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1829
End
1914
Integrated sequence
CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chr1
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
121484066/121742268 (Hg38)
End
121484148/121742350 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/4647540; hsa-mir-1182/Downstream/24108237;
Nearest TSS
ENST00000473358/Upstream/161744; ENST00000443018/Downstream/21758162;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/222541, chr1-CpG: 312/Downstream/3343159
Upstream sequence
TGTTTATTGTTGGCATAAATGATAATACATTATATTAAAAAGACAACTAAACATTGGGATCTCTAGATGGAAGTAGTTTAAAAAATATTTTCTTCCTCTA
Downstream sequence
cactctttttctggaatttgcaagtggagatttcagccgctttgtggtaaatggtagaaaaggaaatatcttcgtataaaaactagatagaatgattctc
Target sequence
gaagaattctcagtaacttccttgtgttgtgtgtattcaactcacagagttgaacgatcctttacacagagcagacttgaaa
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate