Basic Information
VIS ID
TVIS10016975
Fusion event
HBV-chr1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2843
End
2881
Integrated sequence
TACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTG
Host Sequence
Chromosome
chr1
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
121485174/121743376 (Hg38)
End
121485223/121743425 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/4648648; hsa-mir-1182/Downstream/24107162;
Nearest TSS
ENST00000473358/Upstream/162852; ENST00000443018/Downstream/21757087;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/223649, chr1-CpG: 312/Downstream/3342084
Upstream sequence
CTTAGTTCCTTACAACTGAAAATCAGTTAACTAGTGGGTTAGGAGTAGACTTAAGAATCAAAGAAATAGGTAATTTTCACATATCCTGGGCCGCCTTGGC
Downstream sequence
gaaaaggaaatatcttcgtatagaaacaagacagaatgattctcagaaactcctttgtgatgtgtgcgttcaactcacagagtttaacctttcttttcat
Target sequence
tttgtggaatttgcaagtggagatttcagccgctttgaggtcaatggta
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate