Basic Information
VIS ID
TVIS10016976
Fusion event
HBV-chr8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1639
End
1718
Integrated sequence
TTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTG
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
94115512/93103283 (Hg38)
End
94115607/93103378 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/73444; hsa-mir-10400/Downstream/812644;
Nearest TSS
ENST00000518652/Upstream/85610; ENST00000522598/Downstream/31431;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/137042, chr8-CpG: 100/Downstream/596760
Upstream sequence
atggaattactcaaaaaaattatttacttctatcccagggatccacaagcaatacccatgggtaaaatctgatcctcagtttttataaataaagttttat
Downstream sequence
TTTTTCCATcacacacatacacacacacatatgcatgcacacacatacacatgcacacacacaAATCACCATTAATGAACAACATCTAATCATCTGATCT
Target sequence
CAAACTGAAAAGCCCACAAAAAAATGTTAAAACAAAAAGTACACTCAACTCCACTTCATCCTGAGTCTCTGCCTTTAAACATTAAAAAGCTGTGA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate