Basic Information
VIS ID
TVIS10016977
Fusion event
HBV-chr8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2238
End
2327
Integrated sequence
GAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACA
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
94115323/93103094 (Hg38)
End
94115399/93103170 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/73255; hsa-mir-10400/Downstream/812852;
Nearest TSS
ENST00000518652/Upstream/85421; ENST00000522598/Downstream/31639;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/136853, chr8-CpG: 100/Downstream/596968
Upstream sequence
CAACAGGGAAATGAAGGTGAAAACAATTGCTCTATTTAGGCAGAAATGTATATTTCTATATATAGAAGCCAAGATATTCCTCTCCCATCATGCAGCCATG
Downstream sequence
TTTCTTTAAGCGTAATGAAGAAGCTGAAGATTTTGAGTGTTAACTTTTACACTTCAGGAAATGTTGTTATTTACAAGTGAGAAATTTGGAAAAGCCAAAT
Target sequence
AAACTCTGCTTCCATTTTATTGACAATTTTCTTTAATAACGATATTTTTAGGCAGTTAATCGTCCTAAACCTTTTT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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