PHLDB2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016980
Fusion event
HBV-PHLDB2 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1943
End
2032
Integrated sequence
GTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTC
Host Sequence
Chromosome
chr3
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
111653263/111934416 (Hg38)
End
111653361/111934514 (Hg38)
Location type
Intron
Target gene
PHLDB2
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-1-3p ; hsa-mir-432-5p ; hsa-mir-376a-5p ; hsa-mir-382-3p ; hsa-mir-29c-3p ; hsa-mir-148a-3p ; hsa-mir-148b-3p ; hsa-mir-152-3p ; hsa-mir-202-5p ; hsa-mir-298 ; hsa-mir-4709-3p
Nearest miRNA
hsa-let-7g/Upstream/2331519; hsa-mir-12124/Downstream/178287;
Nearest TSS
ENST00000440867/Upstream/22806; ENST00000491694/Downstream/5013;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/74524, chr3-CpG: 40/Downstream/44378
Upstream sequence
TTttttctttctttctttgttacttttttttttttgagatggagtcttgctctgtcacccaggctagagtacagtggcacactctgggctcactgcaatc
Downstream sequence
ATTTTATTAAACTGCATATTGAATACTTCAGCTGAAATTGTAGAATGATTTTGTGCATGCAGCATAATGACTTGTGGCTGGTCTTCCTACCTTTAAACAT
Target sequence
GCATTTAAACTAGATTTAATAAAGTTTGTTTTATTATAAATAGCTTCATTAGGTGGTAAGTCACACAAAGTAAAAAATAAAAGAATAAGAAGAAAGTT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate