PHLDB2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016981
Fusion event
HBV-PHLDB2 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2689
End
2779
Integrated sequence
GGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTAT
Host Sequence
Chromosome
chr3
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
111653157/111934310 (Hg38)
End
111653256/111934409 (Hg38)
Location type
Intron
Target gene
PHLDB2
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-1-3p ; hsa-mir-432-5p ; hsa-mir-376a-5p ; hsa-mir-382-3p ; hsa-mir-29c-3p ; hsa-mir-148a-3p ; hsa-mir-148b-3p ; hsa-mir-152-3p ; hsa-mir-202-5p ; hsa-mir-298 ; hsa-mir-4709-3p
Nearest miRNA
hsa-let-7g/Upstream/2331413; hsa-mir-12124/Downstream/178392;
Nearest TSS
ENST00000440867/Upstream/22700; ENST00000491694/Downstream/5118;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/74418, chr3-CpG: 40/Downstream/44483
Upstream sequence
GAGTGAAACAAAAGATCTTTCAGATGAGGTGTGAATTGAACTAATGTTAACTACATATTTATTATCCTATCAGTTGTCTGAGAGTCAAACCAATGACTTC
Downstream sequence
CCCTTGGGCATTTAAACTAGATTTAATAAAGTTTGTTTTATTATAAATAGCTTCATTAGGTGGTAAGTCACACAAAGTAAAAAATAAAAGAATAAGAAGA
Target sequence
GTAAGTCCTAAAGTTCACTTTAGGACCTTTCTGTGTTATCACAGCTTATCTCCCTTTAGACTTCAAACACTTCAAAATATGACTTCACTACAAAGCTTT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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