Basic Information
VIS ID
TVIS10016984
Fusion event
HBV-LINC02319 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2888
End
2970
Integrated sequence
TTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTG
Host Sequence
Chromosome
chr14
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
52591733/52125015 (Hg38)
End
52591786/52125068 (Hg38)
Location type
Intronic
Target gene
LINC02319
Nearest miRNA
hsa-mir-208a/Upstream/1825069; hsa-mir-1185-1/Downstream/1823359;
Nearest TSS
ENST00000550708/Upstream/55787; ENST00000553372/Downstream/4557;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/55011, chr14-CpG: 108/Downstream/142421
Upstream sequence
caacaacaacaacaacaaACCCATTAAAACTCATCGGGAGTATGAATGGACAAAATATCAAAAAAATTTTTGTGGGGGAAAAAGAAGGAGGAGGGTAAAC
Downstream sequence
GGGGCAGCAGCAAGCTCATATTTCTTTTGGTTAGTTCCTTCACCATGGTTGCCAGTCTCAGTAAAGCTGAGTGTTCCTATCTCCGCCTCTGTCTCCCTCA
Target sequence
TCCCTAAGGGACACTACAGGAAACCAGCCCCGAAGTGATTTCTTTTGAAATTC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate