hsa-mir-4529-3p _LIHC.png
CACNA2D3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016985
Fusion event
HBV-CACNA2D3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2869
End
2958
Integrated sequence
CAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAA
Host Sequence
Chromosome
chr3
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
54760922/54726895 (Hg38)
End
54761019/54726992 (Hg38)
Location type
Intron
Target gene
CACNA2D3
miRNAs that regulate target gene
hsa-mir-18a-3p ; hsa-mir-8058 ; hsa-mir-4529-3p ; hsa-mir-5009-5p ; hsa-mir-1269b ; hsa-mir-1269a ; hsa-mir-6516-3p ; hsa-mir-92a-1-5p ; hsa-mir-6503-3p ; hsa-mir-8075 ; hsa-mir-8069 ; hsa-mir-664a-3p ; hsa-mir-758-5p ; hsa-mir-4728-3p ; hsa-mir-6074
Nearest miRNA
hsa-let-7g/Upstream/1880343; hsa-mir-12124/Downstream/1125500;
Nearest TSS
ENST00000440867/Upstream/454121; ENST00000471865/Downstream/174263;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/100284, chr3-CpG: 24/Downstream/743181
Nearest cancer related gene
CACNA2D3(TSG, No orient, 0)
Upstream sequence
AAGTTTAAGGCCCCCACTTCCTCTGCAAGGCAAGCTGAACATTTACAACCAGTGAAGATTAGCCAAGAGGGAGGAAAGGGAATTGGGACAAACATAGACT
Downstream sequence
gaagatttttgcaatctatccagctgacaaagggctaatatccagaatctacaaagaactgaaatgtataagagaaaaacaaccccatcaaaaagtgggc
Target sequence
aagccaaaattgacaaatgggagctaattaaactaaagagcttctgcaaagcaaaagaaactatcgtcagagtgaacaggcaacctacagaatggga
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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