Basic Information
VIS ID
TVIS10016987
Fusion event
HBV-chr8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2993
End
3083
Integrated sequence
GCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAG
Host Sequence
Chromosome
chr8
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
111636371/110624142 (Hg38)
End
111636470/110624241 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/6139677; hsa-mir-10400/Downstream/2019252;
Nearest TSS
ENST00000518652/Upstream/14901; ENST00000520749/Downstream/142622;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/648299, chr8-CpG: 21/Downstream/2808356
Upstream sequence
AATTTCTATCATTATGAAAACAGAAAAAAGAACTTAGAAGCAAGTTATgcattaccaccaactcacagtgtgaccccagaatgcaattcaacctctctgg
Downstream sequence
tattgttatgttttgtggaaaatgcttttatgattccctttcttcatcagcacatttgctaagtctagaattttaacttagcagtcatttttactgaaat
Target sequence
ACATTCAAATATTTACAAGTTTTTAAATCTTCATGGTTTttctgcttgaaataccgtctgtagaatttcctttagtggcaatctgctgggaattatctc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate