Basic Information
VIS ID
TVIS10016990
Fusion event
HBV-chr1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1904
End
1990
Integrated sequence
GGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCT
Host Sequence
Chromosome
chr1
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
106922020/106379398 (Hg38)
End
106922121/106379499 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/6098090; hsa-mir-11399/Downstream/1517724;
Nearest TSS
ENST00000473358/Upstream/298237; ENST00000415910/Downstream/438740;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/298166, chr1-CpG: 104/Downstream/677084
Upstream sequence
GCAAAGCACCAATACAGTGGCTGAAAACTAGCAGGCCCTCCGTAACGGGCACACATCCACGCATCTGTGTCTTTCCCAGCTCCAACCCTACCTCCTCTGA
Downstream sequence
gttacaactttttggttgtcccatagttcttgtatattctgctcattttgttgttgttgtttctctttgctttttcagttttggcagtttctgtttgcca
Target sequence
atgtcaggcattaatttgtgggaaatagttattattgctttaaacatttctgctgttcctttctctccttctgctttttcttgtattcccattatccacat
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate