VISDB Viral Integration Site DataBase

VIS ID

TVIS10016991

Fusion event

HBV-PLAG1 integration

Validated

No

Detection method

Capture-NGS platform

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2019

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Start

1817

End

1903

Integrated sequence

GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCAT

Chromosome

chr8

Cytoband

q12.1

Reference genome

Start

End

57092823/56180264 (Hg38)

Location type

Intron

Target gene

miRNAs that regulate target gene

hsa-mir-107 ; hsa-mir-424-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-26a-5p ; hsa-mir-375 ; hsa-mir-144-3p ; hsa-mir-340-5p ; hsa-mir-29c-3p ; hsa-mir-128-3p ; hsa-mir-103a-3p ; hsa-mir-101-3p ; hsa-mir-98-5p ; hsa-mir-27a-3p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-17-5p ; hsa-mir-5011-5p ; hsa-mir-6867-5p ; hsa-mir-466 ; hsa-mir-3941 ; hsa-mir-4789-3p ; hsa-mir-3190-3p ; hsa-mir-6833-5p ; hsa-mir-23a-3p ; hsa-mir-23b-3p ; hsa-mir-130a-5p ; hsa-mir-323a-3p ; hsa-mir-23c ; hsa-mir-374a-5p ; hsa-mir-5682 ; hsa-mir-552-5p ; hsa-mir-374b-3p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-889-3p ; hsa-mir-4774-5p ; hsa-mir-4490 ; hsa-mir-545-3p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-15a-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-4795-3p ; hsa-mir-126-5p ; hsa-mir-574-5p ; hsa-mir-4789-5p ; hsa-mir-223-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-664b-5p ; hsa-mir-3934-3p ; hsa-mir-1909-5p ; hsa-mir-3158-3p ; hsa-mir-4446-3p ; hsa-mir-5088-5p ; hsa-mir-4643 ; hsa-mir-190a-3p ; hsa-mir-3674 ; hsa-mir-4709-3p ; hsa-mir-767-5p ; hsa-mir-4524a-3p ; hsa-mir-8060 ; hsa-mir-3919 ; hsa-mir-6871-3p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-511-3p ; hsa-mir-2053 ; hsa-mir-569 ; hsa-mir-6832-3p ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-4752 ; hsa-mir-200b-5p ; hsa-mir-200a-5p

Nearest miRNA

hsa-mir-124-1/Upstream/13283890; hsa-mir-10400/Downstream/5534524;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/22677, chr8-CpG: 154/Downstream/30749

Nearest cancer related gene

PLAG1(OG, No orient, 0)

Upstream sequence

tgaacctttgtttggacagagcacttttgaaacactctttttgtagaatctgcaggtggatatttggctagctttgaggatttcgttggaaacggtaatg

Downstream sequence

TCAAGGCTCAATTATACATGGTTACCACTCTCCTAAGACGAATATCTGACACTGATGGAATAAACATTACCAACACCTATTATGTATGGTTCCAGTCTGA

Target sequence

GTTATGAAGACTGATCTCTAGGGATATTAACTAAGAGAGAAAAAGAAGCCACAAGTTCTATGCAGAAAATCACCTGCTTCATTTCCCTACAACAGAGGG