APBA2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016993
Fusion event
HBV-APBA2 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
299
End
337
Integrated sequence
TCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTC
Host Sequence
Chromosome
chr15
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
29222125/28929922 (Hg38)
End
29222211/28930008 (Hg38)
Location type
Intron
Target gene
APBA2
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-615-3p
Nearest miRNA
hsa-mir-1268a/Upstream/439077; hsa-mir-10393/Downstream/2135024;
Nearest TSS
ENST00000557528/Upstream/8285; ENST00000558206/Downstream/31296;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/42860, chr15-CpG: 62/Downstream/173430
Upstream sequence
ttccactgtattgtagttgcctatttgcttgcacttttttccaattagactggagagcagggaccatgactttcctctctatactcatagcacctagtac
Downstream sequence
GGGTAAAACTGGCCCATTCGCATCTCTATAAAAACAGGTAGGAAAAGGTGGAAGGAGCTGAGTTGGGGAGGTGGAAGGGGGGCAAAAGCTATGTCTCCCG
Target sequence
GAGGAAGTGTAGATCTGCCACCCACCTACTAAAGGAAAGGTTGCTTCTGCCCATCCTCAAAGCTGTTGAGCAGTTATTTACCTAGA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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