Basic Information
VIS ID
TVIS10016995
Fusion event
HBV-chr13 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
241
End
331
Integrated sequence
CGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAA
Host Sequence
Chromosome
chr13
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
68656614/68082482 (Hg38)
End
68656695/68082563 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA13B
Nearest miRNA
hsa-mir-1297/Upstream/1864158; hsa-mir-1267/Downstream/9615449;
Nearest TSS
ENST00000623511/Upstream/710095; ENST00000627910/Downstream/795817;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/851155, chr13-CpG: 34/Downstream/902209
Upstream sequence
tgtaggcagcacatagttgggtctttaaaaaatacattgagtcattctatgtctcttaattagatattttagtccttttccactcaaggttatgactaat
Downstream sequence
CCCTAGTTGAGATTATAAAAACAGAAAAGCATGGCTATGGGCATCTCTTATAATTTCTAAGGGGTCAATGTGACCCATTAGAATTGCCCCCACAACCACT
Target sequence
atacatattatatataatatactagatacacacatataatatataatatttttatatataatatatatatatatataACTC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate