Basic Information
VIS ID
TVIS10016998
Fusion event
HBV-chr1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1858
End
1902
Integrated sequence
CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA
Host Sequence
Chromosome
chr1
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
103100123/102634567 (Hg38)
End
103100221/102634665 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/2353259; hsa-mir-11399/Downstream/5262558;
Nearest TSS
ENST00000473358/Upstream/244937; ENST00000414923/Downstream/219177;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1397378, chr1-CpG: 85/Downstream/890805
Upstream sequence
TCTTAACCATAATCTGGGGGAATCTATTAAGTTTACTTAGTCATTCTCACAAATAATCATTCCAGAGTCACCTCCACTTTCTTCATACAAATGAGCCATG
Downstream sequence
TTACTCATGCCTTCTGTGAAATCCAATATATCACCAGGGGTGGCAAGGCACATTATTTGTTTACAAAGATACAAGACAGTTTGCAAAACAAGCAACATTC
Target sequence
tagcagtgactaaaataacaacaaaggaaaagaatctgaagaaagcagcacacacacaacaggtatccaatacaGTTTACTTTTTGCATCATTCAGAT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate