Basic Information
VIS ID
TVIS10016999
Fusion event
HBV-chr7 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
606
End
644
Integrated sequence
CCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGG
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
152182157/152485072 (Hg38)
End
152182242/152485157 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA7I
Nearest miRNA
hsa-mir-10399/Upstream/1051433; hsa-mir-153-2/Downstream/5089179;
Nearest TSS
ENST00000635602/Upstream/21286; ENST00000488782/Downstream/178847;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/20044, chr7-CpG: 51/Downstream/190738
Upstream sequence
atttttcacaggaagagaaaaaaataaataaatattgtatgaaactgcaaaagaccccaaatagccaaagcaatgttgaacaaacagaacaaagctcaag
Downstream sequence
tcctcccaaagtgctgggattacaggcgtgagccaccgtgcccagcTCTATTTCCTTCTTTCTATTCCCAGTATTATCCCTTTAGTTTAAACACCATGAA
Target sequence
aattgtatttttagtagaaatagggattcaccatgttggccaggctggtcttgaactcctggcctcaggtgatctgcccacctcg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate