Basic Information
VIS ID
TVIS10017002
Fusion event
HBV-chr11 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1676
End
1772
Integrated sequence
CAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGT
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
81285243/81574201 (Hg38)
End
81285279/81574237 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10392/Upstream/2151975; hsa-let-7a-2/Downstream/316504;
Nearest TSS
ENST00000527297/Upstream/811375; ENST00000526154/Downstream/396757;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/2133041, chr11-CpG: 25/Downstream/1115306
Upstream sequence
AGAAAGGAAGAAAGCCTTGCTAGAAATAATAAATAATCTCACGCAAAAGGCCAGGTGACATAAGAATACTACAATAATCAATATGTTTTCTTTGTATTTA
Downstream sequence
GACTAGGCACATTCAATATTTCCATTGAAGAAATGTGTCTTTACCAGGtgatatggtttggctgtatccccccacaaatctcatcttaaattgtaatccc
Target sequence
CATTGCTTTAATTATTTTTTAAAACTATGTTTCTGT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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