Basic Information
VIS ID
TVIS10017003
Fusion event
HBV-JHY integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2345
End
2417
Integrated sequence
TGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGT
Host Sequence
Chromosome
chr11
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
122788740/122918032 (Hg38)
End
122788812/122918104 (Hg38)
Location type
Intron
Target gene
JHY
miRNAs that regulate target gene
hsa-mir-10a-5p
Nearest miRNA
hsa-let-7a-2/Upstream/765724; hsa-mir-3167/Downstream/463336;
Nearest TSS
ENST00000527297/Upstream/32274; ENST00000534362/Downstream/16936;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/34789, chr11-CpG: 86/Downstream/58682
Upstream sequence
TCGCTAAATCTGACTCCCTTCGTCTAGTCTCTGTTTGGCAGCCCCCGCGCCCCAGAGCAGGTGTTTGGGGCGGGTAGGGGGTGTTTTGGTTTGGTTTTTG
Downstream sequence
tggccaggctggtctcgaactcctggtttcaagtgatctgcctgcctcagcctcccaaactgctgggattacaggtgtgagccactgtgtccagccTagc
Target sequence
tgggattacaggcatgagccaccacacccagctaatttttgtatttttagtagagacagggttttgccatat
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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