VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10017004

Fusion event

HBV-PRORP integration

Validated

No

Detection method

Capture-NGS platform

Data source

Curated

Sample type

Tumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2019

PubMed ID

30070724

Virus Sequence

Virus name

HBV

Subtype

B

Reference genome

NC_003977

Start

2846

End

2931

Integrated sequence

AGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGC

Host Sequence

Chromosome

chr14

Cytoband

q13.2

Reference genome

GRCh37/hg19

Start

35632301/35163095 (Hg38)

End

35632345/35163139 (Hg38)

Location type

Intron

Target gene

PRORP

miRNAs that regulate target gene

hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-2117 ; hsa-mir-148a-5p ; hsa-mir-7856-5p ; hsa-mir-3658 ; hsa-mir-744-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-431-5p ; hsa-mir-193a-5p ; hsa-mir-31-3p ; hsa-mir-4524a-3p ; hsa-mir-4726-3p ; hsa-mir-4781-3p ; hsa-mir-1182 ; hsa-mir-4524b-3p ; hsa-mir-1273e ; hsa-mir-8065 ; hsa-mir-4656 ; hsa-mir-7160-5p ; hsa-mir-202-3p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-4721 ; hsa-mir-4699-5p ; hsa-mir-7162-3p ; hsa-mir-4446-3p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-203b-3p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-6499-3p ; hsa-mir-2467-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-1827 ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4257 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4695-5p

Nearest miRNA

hsa-mir-208a/Upstream/4148353; hsa-mir-1185-1/Downstream/1789170;

Nearest TSS

ENST00000550708/Upstream/40336; ENST00000628955/Downstream/115494;

Nearest CpG islands

None/Target, chr14-CpG: 35/Upstream/40298, chr14-CpG: 31/Downstream/129055

Upstream sequence

CCACATTATTATGCAGATGACATTGCTCATGGTGGATACTAGAGCTGGGGCAGCTGATGAGGAAATCACCAGGGGTGGCTCAGAAAAAAAAAAAATGACC

Downstream sequence

TATTAATAATGCTCCCTGGGGCAAAATCATGTTTTATATATGTGACAGAGTCCTATTACCCgtggcttttaagcgttttttaacacaacacagatacaat

Target sequence

AATAAACTTACCAGAGGTAAATATTATAGGCCTCTGATAAAATG

Reference

Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.