Basic Information
VIS ID
TVIS10017005
Fusion event
HBV-IGH integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1817
End
1844
Integrated sequence
GCAACTTTTTCACCTCTGCCTAATCATC
Host Sequence
Chromosome
chr14
Cytoband
q32.33
Reference genome
GRCh37/hg19
Start
106159965/105693628 (Hg38)
End
106160046/105693709 (Hg38)
Location type
Intronic
Target gene
IGH
Nearest miRNA
hsa-mir-1185-1/Upstream/53396; hsa-mir-4507/Downstream/163804;
Nearest TSS
ENST00000550708/Upstream/23785; ENST00000414005/Downstream/14956;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/6601, chr14-CpG: 18/Downstream/3801
Upstream sequence
attcctaacagtatgacactattttgattattgtagttttatgatatatctaatatctattagagctaatttttataacttGGGTTCTGGCACTTTCTTT
Downstream sequence
cagagacagagacagagtaacagagaaagacagagagacagagagagacagagacagagtaacagagaaagagagacagagagagacacagagacagaga
Target sequence
acagagtaacagagaaagagagacagagagagacacagagacagagacagagtaacagagaaagacagagagacagagaca
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate