Basic Information
VIS ID
TVIS10017006
Fusion event
HBV-chr16 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
412
End
463
Integrated sequence
TCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTAT
Host Sequence
Chromosome
chr16
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
46386632/46391446 (Hg38)
End
46386733/46391547 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/12227773; hsa-mir-11401/Downstream/3901069;
Nearest TSS
ENST00000527434/Upstream/10604559; ENST00000569239/Downstream/192706;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10288733, chr16-CpG: 124/Downstream/35911
Upstream sequence
AGATTTGCTGTTGGGGCCCTCACTGGGGAGGGGTGGTCTGGACTGAGAAGGAGGTGGAGAAGCTGCCAGGGACCCTTTTGGATCCAGAATTGAGGCAGCA
Downstream sequence
ccatttgatgactattccattcaaatccatttgatgattccattcgattccattcgatgttaccattcgagtatatacgatgattccactcgattccatt
Target sequence
tttcctatcgatgaagattccattcaagtgtattcgatgattccattcaaatccattcgatgatgattccattccagtccattcgatcattccacttgatt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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