Basic Information
VIS ID
TVIS10017007
Fusion event
HBV-chr16 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1830
End
1921
Integrated sequence
CTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr16
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
46386535/46391544 (Hg38)
End
46386635/46391644 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/12227871; hsa-mir-11401/Downstream/3900972;
Nearest TSS
ENST00000527434/Upstream/10604657; ENST00000569239/Downstream/192609;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10288831, chr16-CpG: 124/Downstream/35814
Upstream sequence
attcgagttcattcgatgattgcattcgagtccatttgatgattccatatgattcccttcgacaatgattccattcgtgtccatttgatgattccattca
Downstream sequence
cctatcgatgaagattccattcaagtgtattcgatgattccattcaaatccattcgatgatgattccattccagtccattcgatcattccacttgattcc
Target sequence
cgagttcattcgatgattgcattcgagtccatttgatgattccatatgattcccttcgacaatgattccattcgtgtccatttgatgattccattcattt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate