hsa-mir-6780a-3p _LIHC.png
AFF3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017008
Fusion event
HBV-AFF3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2692
End
2747
Integrated sequence
ATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTA
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
100247186/99630724 (Hg38)
End
100247254/99630792 (Hg38)
Location type
Intron
Fragile sites / regions
FRA2S ; FRA2A
Target gene
AFF3
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-6867-5p ; hsa-mir-3177-5p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-1227-3p ; hsa-mir-4252 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-1273g-3p ; hsa-mir-508-5p ; hsa-mir-6849-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/2832371; hsa-mir-10b/Downstream/1678658;
Nearest TSS
ENST00000437798/Upstream/52354; ENST00000434301/Downstream/376053;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/36695, chr2-CpG: 138/Downstream/473131
Nearest cancer related gene
AFF3(OG, No orient, 0)
Upstream sequence
AAGTGAATGTAGTTTCATGAGTGTGGAATATTTGTAGCATATTAAAATTGCTCTCTAGGTACAGTTAGCTTATCCCTTATGGTTTTACCCTGCTGTAAGG
Downstream sequence
actcccataatccaatcacctcccaccaggtccctctcttgacatgtggggatgacaattccagatgagatttgggtggtgacacagagccaaaccatat
Target sequence
aagtgccacccttttaaaaccatcaccttgagtgagaactcactcacaagaacagcatgggggaaacc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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