Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017009
Fusion event
HBV-PPP1R1C integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
Start
1935
End
1978
Integrated sequence
ACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTC
Host Sequence
Chromosome
chr2
Cytoband
q31.3
Reference genome
End
182826372/181961645 (Hg38)
Location type
Intron
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-146a-5p ; hsa-mir-3119 ; hsa-mir-5191 ; hsa-mir-6894-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-4521 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-7158-5p ; hsa-mir-767-3p ; hsa-mir-6826-5p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-3977 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4712-5p ; hsa-mir-4768-3p ; hsa-mir-770-5p ; hsa-mir-936
Nearest miRNA
hsa-mir-10b/Upstream/655906; hsa-mir-1244-1/Downstream/2417330;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/68766, chr2-CpG: 53/Downstream/754321
Upstream sequence
TTCTCAATTTCTCATCAGTTATTTTCCTGGCAAGTTATCTCAGCAAAACATATTTTTTACATTATATTTGACAAATAATAGAAGCTTTGCATTGATAAGA
Downstream sequence
TGCTCTTCTCAATCTGCTGAGACCAGCACTTGTCCAGCTCCTCTCAGTTCTTTCGAGTCAGCTCATCATATTGGGCCCGGATATCTGCTATGATCTTGGC
Target sequence
TCTTTAAGGACTGGACTGTACGTCTCAGCTCCGTGAGCGTCATCTCAGCATCTCCAACCTTGGTGGACTGCGTAGTGACCACTGTGG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.