Basic Information
VIS ID
TVIS10017010
Fusion event
HBV-chr20 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
443
End
521
Integrated sequence
TCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGG
Host Sequence
Chromosome
chr20
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
55648237/57073181 (Hg38)
End
55648290/57073234 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/3004696; hsa-mir-1-1/Downstream/248268;
Nearest TSS
ENST00000382410/Upstream/342784; ENST00000442780/Downstream/32507;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/147135, chr20-CpG: 26/Downstream/18837
Upstream sequence
GGGGCTCTGCAAAGGTGATGCTATGCCTATGTGATAAGAGCATACTTATTCTGTTTGTTTAGAAAGCTTTTTGCATATTTGATATTACTGACAACAAAAA
Downstream sequence
cagaaggaggtggggtcttcctggggtgaggggggccgtgttccacgtcttgttctgagtgtggaagggtgtacatgtttgccacaatgtatcaaatgcc
Target sequence
cagaaggccagaaccaatctgcagccagaaagcagcaccacggccacccaggg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate