PDSS2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017011
Fusion event
HBV-PDSS2 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2846
End
2888
Integrated sequence
AGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCT
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
107657496/107336292 (Hg38)
End
107657576/107336372 (Hg38)
Location type
Intron
Fragile sites / regions
FRA6F
Target gene
PDSS2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-142-3p
Nearest miRNA
hsa-mir-10398/Upstream/552072; hsa-mir-1202/Downstream/11732675;
Nearest TSS
ENST00000381078/Upstream/124133; ENST00000618129/Downstream/123191;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/220186, chr6-CpG: 19/Downstream/122659
Nearest cancer related gene
PDSS2(TSG, No orient, 0)
Upstream sequence
AAAATTTATCAAATATCAAAATTCTTTCCTAAATCCAAAGCTAGTGAAAAATTAGGTCTCAAATAAAAAGGAACATAGAACTGATAAAGACAGTCATAGT
Downstream sequence
TCTGCAAAGTAACAGCTATAGCTTTCTCTGCTTATATTCTGTCCTTAACCAAGTAGGCAATCTTCATCAAGATAAAAGGGTTTAAACTGATTTTTAAAAA
Target sequence
TCCAGTCTCCAAACAGAAATTTTTAAAAGGGGCCCCTTTTACCTTTCATTAGTTTCAAAATAAGACAAATCATTAGGTTC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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