Basic Information
VIS ID
TVIS10017012
Fusion event
HBV-chr10 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2462
End
2554
Integrated sequence
GGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATAC
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
135524661/133787336 (Hg38)
End
135524747/133787422 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/415673;
Nearest TSS
ENST00000439456/Upstream/160541;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/26089, None/Downstream
Nearby gene
RPL23AP60(-8086) ;
Upstream sequence
TTAATAGAAAATAGGCTCCACTGAGTTAAAAATTATCTCCAACAGTTCTTTAACTCAGTGACTATTGATCTGGTGGCAAGAAATGGTTCATTTGTCAGAG
Downstream sequence
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
Target sequence
ggttagggtgagggttagggttagggttagggtgagggttagggttagggtgagggttagggttagggtgagggttagggttaggg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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