Basic Information
VIS ID
TVIS10017016
Fusion event
HBV-chr8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1711
End
1801
Integrated sequence
AAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCT
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
36491778/36634260 (Hg38)
End
36491877/36634359 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/6676912; hsa-mir-10400/Downstream/4636689;
Nearest TSS
ENST00000518652/Upstream/539214; ENST00000522417/Downstream/144805;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1397667, chr8-CpG: 351/Downstream/1060067
Upstream sequence
acaaaaacaaaatgaaaaaccataaacaggacctcagagacatgtaggatactgcagagcacatgggtatgtgcatagcacgagcacagaagcagaggag
Downstream sequence
AGAGGGCTTTGTTTTGTCACCTACTTCTGGTCATCAGAATAGGAAGCTGTGAGCTGTCTGAGGAAGGTTCAGGATTGCACCTGTCAAAATAACTTAATGT
Target sequence
GTTTTATTAGATGCTTTCTGGAAGTTTGCCTTAATCTCAGTATGGTATTTTCTGAAGTGTACTAAAACAACTGGATTAATGGGGGATATATTTGGAAGA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate