Basic Information
VIS ID
TVIS10017017
Fusion event
HBV-chr12 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1829
End
1914
Integrated sequence
CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chr12
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
128338638/127854093 (Hg38)
End
128338738/127854193 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA12E
Nearest miRNA
hsa-let-7i/Upstream/2938434; hsa-mir-3612/Downstream/439899;
Nearest TSS
ENST00000382841/Upstream/32910; ENST00000536342/Downstream/27424;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/92802, chr12-CpG: 196/Downstream/412303
Upstream sequence
tgttggcaactgtatttatacccacttatacctactttcagttacatgcaaattaaggggcaagctaatgcaaattgatgggtgggttatttagaacttt
Downstream sequence
acatgtacatctttaattcatttctagttaatttttatatggtgtaagatgaggatccgatttcattgacttgcatgtgaataaccgatttactgcaaac
Target sequence
ttgtttggtgtccaaagggagaaaaaaatcattgccaaggccagtgtaaagagcttttcttcctacgtgttctcctaggcattttatcattttagattct
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate