Basic Information
VIS ID
TVIS10017019
Fusion event
HBV-chr18 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1778
End
1826
Integrated sequence
GAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT
Host Sequence
Chromosome
chr18
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
18518727/20938766 (Hg38)
End
18518819/20938858 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-3156-2/Upstream/6108524; hsa-mir-1-2/Downstream/744660;
Nearest TSS
ENST00000575820/Upstream/5774299; ENST00000579454/Downstream/16012;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/5607591, chr18-CpG: 113/Downstream/172121
Upstream sequence
AACCTTAGTTTAGGCTGCCAAAAGGAGCAATGGGCTGGGTGCCATGGTCCAGCTCCAGGAGGGCTTTGAGTTGGCCATGGTCATTGCCAAGTGGCAATGT
Downstream sequence
ctgagtacacacatcacagacaagtttctgagaatgcttctgtctattttttatgggaagatatttcctttttcaccataggcgtcaaagcgctcgaaat
Target sequence
aatcctaaaatctatccaaatatccacttgcagattctacaaaaagagtgtttcaaaactgctctgtgaaaagaaagcttcaactctgttag
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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