Fusion event
HBV-C1orf94 integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
AGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAA
End
34654665/34189064 (Hg38)
Nearest miRNA
hsa-mir-12136/Upstream/856473; hsa-mir-101-1/Downstream/480535;
Upstream sequence
CAGAGCATCACCAGGCCAATATGCATGAAGACTGAGGTTTTAAAGGAGAGGATCTCACGCAGGTTGTACAAGAAGAGCAAACACAACTGACCTGGAGAGC
Downstream sequence
tatgtgtacatgggtgtgtgcataggtgtgcatgtgtatgcatggatgtgtgttcatgtgtgcaggatgtgtgtgtatggatgtgtgtgcatggctgtgt
Target sequence
ACCTTCCTTCCCTGTTTTCTTTCCTTCCTGCTGGTTTTCCAAGCAGGAAGGCTACGGTGGTTtgtgtgtttgtgtgtgtatgtgcatgggtgtggtgtg
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.