Basic Information
VIS ID
TVIS10017025
Fusion event
HBV-chr4 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2456
End
2544
Integrated sequence
TTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTT
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
64534520/63668802 (Hg38)
End
64534617/63668899 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/2746118; hsa-mir-1243/Downstream/2607925;
Nearest TSS
ENST00000502981/Upstream/174524; ENST00000509473/Downstream/612637;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/318936, chr4-CpG: 32/Downstream/2000576
Upstream sequence
AATGTCATCTTAACATTTAGGCGTTTATTCATAGTAACCAGAAATTGTGTTTTATGCTTTTTATTTTTCCTAATGAAGATGCAATTAATTTAAGATGGCA
Downstream sequence
gttggttattatgctggcttgtttgtgtggttggtttatagtgtcactggactgtgtacataagtgtattttgtaatggcttgtaatagtctttcctttt
Target sequence
gcttgccactctctgccttttaaataaggcatttagcccatttacattcaagattagtattgatatgtgtggatttgatcctgtcattgtgttgtta
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate