Basic Information
VIS ID
TVIS10017026
Fusion event
HBV-chr4 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2909
End
2999
Integrated sequence
CCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAG
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
61065376/60199658 (Hg38)
End
61065475/60199757 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/7486911; hsa-mir-1243/Downstream/722862;
Nearest TSS
ENST00000502981/Upstream/407544; ENST00000509559/Downstream/550829;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/3003709, chr4-CpG: 222/Downstream/1000408
Upstream sequence
tttattttttgtagtataaattattttGAAGCAAAGAGTATCATCCATTATTCCTTTCACTTCAAAGATCACCTTGAGATTAAACATTTTCTGCAAAATT
Downstream sequence
acaggttacctgtaagagctgaaggtctcaatcttacagtcacaatgtaataaattctgctaacaacctgaatggacttggaaagggatttgtttttcca
Target sequence
atctctgtcactagagttgctcttgctccttgctggctctgaagaagcaagtcattgtgttatgaattacctacagagaagcttccaaggcaaaaaact
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate