Basic Information
VIS ID
TVIS10017039
Fusion event
HBV-DDX11L1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2064
End
2154
Integrated sequence
CTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAG
Host Sequence
Chromosome
chr1
Cytoband
p36.33
Reference genome
GRCh37/hg19
Start
10188/10188 (Hg38)
End
10288/10288 (Hg38)
Location type
Promoter
Fragile sites / regions
FRA1A
Target gene
DDX11L1
Nearest miRNA
hsa-mir-101-1/Downstream/7081;
Nearest TSS
ENST00000473358/Downstream/19266;
Nearest CpG islands
None/Target, None/Upstream, chr1-CpG: 111/Downstream/18447
Upstream sequence
GGTTTGCTTTTTAAAAGTTTGAAGTTATATTTGAGACCCCATACTTCTAGAATTCTGACCCTAAGCCATAATTCAGTCTTTCTAAATGAGAATCTCTTCT
Downstream sequence
cccaaccccaaccccaaccccaaccccaaccccaaccctaacccctaaccctaaccctaaccctaccctaaccctaaccctaaccctaaccctaacccta
Target sequence
ccctaaccctaaccctaaccctaaccctaaccctaaccctaacccctaaccctaaccctaaaccctaaaccctaaccctaaccctaaccctaaccctaac
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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